Autoimmune thrombocytopenia in Waldenstr�m's macroglobulinemia
نویسندگان
چکیده
منابع مشابه
Autoimmune thrombocytopenia: a complication of fludarabine therapy in the treatment of Waldenstrom's macroglobulinemia.
Fludarabine is an effective purine analogue which has become extensive used in lymph proliferative malignancies. However, an increased incidence of autoimmune disorders including autoimmune hemolytic anemia (AHIA) and idiopathic thrombocytopenia (ITP) is reported with the use of fludarabine. The exact mechanism for fludarabine to exacerbate thrombocytopenia is not distinct. In our report, we de...
متن کاملSevere Thrombocytopenia in a Splenectomized Patient with Waldenstrom Macroglobulinemia
Introduction. Patients with Waldenström macroglobulinemia (WM) can present with a diverse array of findings. One such manifestation is autoimmune thrombocytopenia which may occur as a consequence of autoantibody activity against platelets. Case Presentation. We report a case of a 57-yearold African American male who presented with a two-week history of fatigue, recurrent epistaxes and gingival ...
متن کاملPlatelet-bound IgM in autoimmune thrombocytopenia.
Elevated levels of platelet-bound IgG (PA-IgG) are a feature of autoimmune thrombocytopenia (ATP), but it is well documented that this does not occur in all cases. This has led us to investigate the role of platelet-bound IgM (PA-IgM) in these patients using a quantitative enzyme-linked immunosorbent assay (ELISA). Forty-five determinations of PA-IgM and PA-IgG were done on 24 patients with ATP...
متن کاملSpecificity of autoantibodies in autoimmune thrombocytopenia.
In 42 patients with autoimmune thrombocytopenia (AITP) and a positive direct platelet suspension immunofluorescence test (PSIFT), the antigenic specificity of the autoantibodies was studied. Because the autoantibodies were often not detectable in the serum and additional HLA antibodies may disturb the reaction pattern with the platelet panel, we used eluates prepared from the patients' platelet...
متن کاملNeonatal alloimmune thrombocytopenia complicated by maternal autoimmune thrombocytopenia.
Neonatal alloimmune thrombocytopenia should be suspected in any thrombocytopenic infant born to a healthy non-thrombocytopenic mother. Nevertheless, the condition occurs in only 1 or 2/10 000 births.' More often transient neonatal immune thrombocytopenia results from maternal idiopathic thrombocytopenic purpura. We report the coexistence of alloimmunisation and autoimmunisation against platelet...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2001
ISSN: 0361-8609,1096-8652
DOI: 10.1002/1096-8652(200102)66:2<116::aid-ajh1026>3.0.co;2-v